![]() ![]() As such, myocardial triglyceride may become a potential therapeutic target to treat the increasing number of patients with HFpEF.Ĭardiovascular magnetic resonance Diastolic strain rate Heart failure Maximal oxygen consumption Spectroscopy Steatosis. Steatosis may adversely affect exercise capacity by indirect effect occurring via impairment in diastolic function. Myocardial steatosis is pronounced in mild HFpEF, and is independently associated with impaired diastolic strain rate which is itself related to exercise capacity. On multivariate analyses, MTG was independently associated with diastolic strain rate while diastolic strain rate was independently associated with VO 2 max. ![]() HFpEF had significantly reduced diastolic strain rate and maximal oxygen consumption (VO 2 max), which both correlated significantly with elevated MTG and reduced PCr/ATP. ![]() When compared to controls, HFpEF had 2.3 fold higher in MTG (1.45 ± 0.25% vs. Twenty seven HFpEF (clinical features of HF, left ventricular EF >50%, evidence of mild diastolic dysfunction and evidence of exercise limitation as assessed by cardiopulmonary exercise test) and 14 controls underwent 1H-cardiovascular magnetic resonance spectroscopy ( 1H-CMRS) to measure MTG (lipid/water, %), 31P-CMRS to measure myocardial energetics (phosphocreatine-to-adenosine triphosphate - PCr/ATP) and feature-tracking cardiovascular magnetic resonance (CMR) imaging for diastolic strain rate. We measured myocardial triglyceride content (MTG) in HFpEF and assessed its relationships with diastolic function and exercise capacity. However its role in mild HF with preserved ejection fraction (HFpEF) is uncertain. Heart failure (HF) is characterized by altered myocardial substrate metabolism which can lead to myocardial triglyceride accumulation (steatosis) and lipotoxicity.
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